3 edition of Carbohydrate modifications in antisense research found in the catalog.
|Statement||Yogesh S. Sanghvi, editor, P. Dan Cook, editor.|
|Series||ACS symposium series,, 580|
|Contributions||Sanghvi, Yogesh S., 1956-, Cook, P. Dan, 1944-, American Chemical Society. Division of Carbohydrate Chemistry., American Chemical Society. Meeting|
|LC Classifications||QP623.5.A58 C37 1994|
|The Physical Object|
|Pagination||viii, 232 p. :|
|Number of Pages||232|
|LC Control Number||94038930|
Chemical modifications at the backbone, sugar and/or base have been shown to stabilize oligonucleotides to enzymatic digestion with a t 1/2 >24 h (6,9,15). The first generation antisense drug on the market is a DNA analog where one of the non-bridging oxygen atoms in the phosphodiester bond is replaced by sulfur. fig2: Chemical modifications of antisense oligonucleotides. The structures of several important forms of antisense oligonucleotides are illustrated. Phosphorothioates can be considered first generation–modified oligonucleotides, whereas additionally modified compounds that retain the carbohydrate–phosphate backbone can be considered second generation (e.g., 2′-O-methoxy-ethyl.
He is an editor of ACS book entitled Carbohydrate Modifications in Antisense Research published in In May , he founded Rasayan Inc., a company focused on the consulting, outsourcing services and supply of products related to nucleic acid field. Advances in Carbohydrate Chemistry and Biochemistry, Vol presents a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry. Since its inception in , the series has provided critical and informative articles written by research specialists that integrate the industrial, analytical and technological aspects of biochemistry, organic.
visitor survey. We are always looking for ways to improve customer experience on We would like to ask you for a moment of your time to fill in a short questionnaire, at the end of your visit. If you decide to participate, a new browser tab will open so you can complete the survey after you have completed your visit to this website. Inhaled oligonucleotide is an emerging therapeutic modality for various common respiratory diseases, including obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD) and restrictive airway diseases like idiopathic pulmonary fibrosis (IPF). The advantage of direct accessibility for oligonucleotide molecules to the lung target sites, bypassing systemic.
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Meeting\/span>\n \u00A0\u00A0\u00A0\n schema:datePublished\/a> \" \/span>\" ; \u00A0\u00A0\u00A0\n schema:description\/a> \" Carbohydrates: synthetic methods and applications in antisense therapeutics: an overview \/ Yogesh S. Sanghvi and P. Dan Cook -- Novel backbone replacements for oligonucleotides \/ Alain De Mesmaeker, Adrian Waldner.
4 CARBOHYDRATE MODIFICATIONS IN ANTISENSE RESEARCH in modifications of the phosphorus atom of the phosphodiester linkage, such as phosphorothioates (7), phosphorodithioates (#), methylphosphonates (9), phosphoramidates (10), boranophosphates (77), phosphonofluoridates (72), and phosphate esters (75), which are adequately covered elsewhere.
Carbohydrate Modifications in Antisense Research. Edited by Yogesh S. Sanghvi, and P. Dan Cook, ACS Symposium Series American Chemical Society; Washington, DC. Carbohydrate modifications in antisense research: developed from a symposium sponsored by the Division of Carbohydrate Chemistry at the th National Meeting of the American Chemical Society, San Diego, California, March[Yogesh S Sanghvi; P Dan Cook; American Chemical Society.
Division of Carbohydrate Chemistry. The 2′-position of the carbohydrate moiety has proven to be a fertile position for oligonucleotide modifications for antisense technology.
The 2′-modifications exhibit high binding affinity to target RNA, enhanced chemical stability and nuclease resistance and increased by: Bellon L, Leydier C, Barascut JL () 4-Thio RNA: a novel class of sugar-modified B-RNA. In: Sanghvi YS, Cook PD (eds) Carbohydrate modifications in antisense research.
American Chemical Society, Washington DC, pp 68–79 CrossRef Google Scholar. “Carbohydrates: Sythetic Methods and Applications in Antisense Therapeutics: An Overview” In Carbohydrate Modifications in Antisense Research.
ACS Symposium Series ACS Symposium Series YS Sanghvi and PD Cook, eds. ACS Publications, 1– A multivalent carbohydrate recognition motif for the asialoglycoprotein receptor has been designed for tissue- and cell-specific delivery of antisense drugs to parenchymal liver cells.
O‐Acetylation and Other Sialic Acid Modifications in Carbohydrate Ligands. Inhibitors of Selectin‐Mediated Cell Adhesion Use of Carbohydrate Derivatives. Use of Peptide Mimetics. Regulation of Selectin Expression on Endothelial Cells Enhanced.
Structural modifications of antisense oligonucleotides Article Literature Review in Il Farmaco 58(3) April with 25 Reads How we measure 'reads'.
An interesting research direction which might make modified nucleosides more easily available is the development of fermentation processes using biotechnologically engineered microorganisms.
In contrast to most drugs, antisense oligomers have to be taken up by target cells in order to exert their activity. Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis.
A lot of structural modifications around the anomeric center of carbohydrates has been achieved over the last decade, and these are summarized in terms of the different chemical and biological aspects of carbohydrate mimics in one part of this book.
In addition to the well established fields of C-glycosides, azasugars and carbasugars the other. Item is published but has no ISSN. Synthesis characterization and pairing properties of an alpha-DNA-analogue with restricted conformational flexibility in the sugar-phosphate backbone: (alpha-bicyclo-DNA).
2′-Carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression(1), DOI: /S(99) Antisense oligonucleotides are now entering the clinic for hard-to-treat diseases.
New chemical modifications are urgently required to enhance their drug-like properties. We combine amide coupling with standard oligonucleotide synthesis to assemble backbone chimera gapmers that.
Language: English ISBN:LCCN: MeSH: Carbohydrates/genetics; Oligonucleotides, Antisense/chemical synthesis* Publication Type(s): Congresses Notes: "Developed from a symposium sponsored by the Division of Carbohydrate Chemistry at the th National Meeting of the American Chemical Society, San Diego.
Investigation of Some Properties of Oligodeoxy-Nucleotides Containing 4′-Thio-2′-Deoxynucleotides: Duplex Hybridization and Nuclease Sensitivity Duplex Hybridization and Nuclease Sensitivity, Nucleic Acids Research, Vol Is 1 NovemberPages –, Carbohydrate Modifications in Antisense Research.
Certain such techniques and procedures may be found for example in “Carbohydrate Modifications in Antisense Research” Edited by Sangvi and Cook, American Chemical Society, Washington D.C., ; “Remington's Pharmaceutical Sciences,” Mack Publishing Co., Easton, Pa., 21′ edition, ; and “Antisense Drug Technology, Principles.
Carbohydrates and Carbohydrate Polymers: Analysis, Biotechnology, Conformation, Modification, Antiviral and Other Commercial Applications (Frontiers in Biomedicine and Biotechnology) by D.
C.) Symposium on Industrial Polysaccharides ( Washington (Author), D. C.) American Chemical Society. Refinements in the chemistries employed in oligonucleotide therapeutics have galvanized clinical progress.
The complex interplay between chemical modifications and integration into sequence.We show here that antisense RNA, which has previously been used only to reduce the expression of genes of known function 10–12, when applied to pTOM13, reduces ethylene synthesis in a gene.Carbohydrate Polymers is a major journal within the field of glycoscience, and covers the study and exploitation of polysaccharides which have current or potential application in areas such as bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine.